Serological diagnosis of avian influenza in poultry: is the haemagglutination inhibition test really the 'gold standard'?

ABSTRACT:

Background

The serological diagnosis of avian influenza (AI) can be performed using different methods, yet the haemagglutination inhibition (HI) test is considered the 'gold standard' for AI antibody subtyping. Although alternative diagnostic assays have been developed, in most cases, their accuracy has been evaluated in comparison with HI test results, whose performance for poultry has not been properly evaluated.

Objective

The objective of this study was to estimate the diagnostic sensitivity (Se) and specificity (Sp) of the HI test and six other diagnostic assays for the detection of AI antibodies without assuming a gold standard.

Methods

We applied a Bayesian version of latent class analysis to compare the results of multiple tests from different study settings re

SUBMITTER: Comin A 

PROVIDER: S-EPMC5779823 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature