Intensity-modulated proton therapy and osteoradionecrosis in oropharyngeal cancer.

ABSTRACT:

Purpose

We compared mandibular doses and osteoradionecrosis in patients with oropharyngeal cancer after intensity-modulated radiation therapy (IMRT) or intensity-modulated proton therapy (IMPT).

Methods and materials

We identified 584 patients who received definitive radiotherapy for oropharyngeal cancer from January 2011 through June 2014 at MD Anderson Cancer Center (534 IMRT and 50 IMPT). The dosimetric variables and osteoradionecrosis were compared with Chi-square test or Fisher's exact test.

Results

Median follow-up time for all patients (534 IMRT and IMPT) was 33.8months (33.8months IMRT vs. 34.6months IMPT, P=0.854), and median time to osteoradionecrosis was 11.4months (range 6.74-16.1months). Mandibular doses were lower for patients treated with IMPT (minimum

SUBMITTER: Zhang W 

PROVIDER: S-EPMC5779856 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature