The ESAT-6 gene cluster of Mycobacterium tuberculosis and other high G+C Gram-positive bacteria.

ABSTRACT:

Background

The genome of Mycobacterium tuberculosis H37Rv has five copies of a cluster of genes known as the ESAT-6 loci. These clusters contain members of the CFP-10 (lhp) and ESAT-6 (esat-6) gene families (encoding secreted T-cell antigens that lack detectable secretion signals) as well as genes encoding secreted, cell-wall-associated subtilisin-like serine proteases, putative ABC transporters, ATP-binding proteins and other membrane-associated proteins. These membrane-associated and energy-providing proteins may function to secrete members of the ESAT-6 and CFP-10 protein families, and the proteases may be involved in processing the secreted peptide.

Results

Finished and unfinished genome sequencing data of 98 publicly available microbial genomes has been analyzed for the

SUBMITTER: Gey Van Pittius NC 

PROVIDER: S-EPMC57799 | biostudies-literature | 2001

REPOSITORIES: biostudies-literature