Whole‑genome scale identification of methylation markers specific for cerebral palsy in monozygotic discordant twins.

ABSTRACT: Cerebral palsy (CP) is a severe type of brain disease affecting movement and posture. Although CP has strong genetic and environmental components, considerable differences in the methylome between monozygotic (MZ) twins discordant for CP implicates epigenetic contributors as well. In order to determine the differences in methylation in patients with CP without interference of the interindividual genomic variation, four pairs of MZ twins discordant for CP were profiled for DNA methylation changes using reduced representation bisulfite sequencing on the genomic‑scale. Similar DNA methylation patterns were observed in all samples. However, MZ twins demonstrated higher correlations and closer evolutionary associations compared with the other samples, indicating a stable methylome of MZ twins.

SUBMITTER: Jiao Z 

PROVIDER: S-EPMC5779998 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature