A novel method to isolate mesenchymal stem cells from mouse umbilical cord.

ABSTRACT: Mesenchymal stem cells (MSCs), derived from various tissues, are considered an ideal cell source for clinical use, among which MSCs from the umbilical cord exhibit advantages over those from adult tissues. In preclinical studies, mouse models and xenogeneic MSC treatment are most commonly used to imitate diseases and clinical practice, respectively. However, the efficiency of cross‑species therapy remains controversial, making it difficult to elucidate the underlying mechanisms. Thus, allogeneic therapy may be more instructive and meaningful in clinical use. To confirm this hypothesis, the present study established a novel method for the isolation and expansion of MSCs from mouse umbilical cords (mUC‑MSCs) to support in vivo experiments in mice. MSCs were isolated from mUCs and mouse bone

SUBMITTER: Zhang B 

PROVIDER: S-EPMC5780165 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature