Comparison of T Cell Activities Mediated by Human TCRs and CARs That Use the Same Recognition Domains.

ABSTRACT: Adoptive T cell therapies have achieved significant clinical responses, especially in hematopoietic cancers. Two types of receptor systems have been used to redirect the activity of T cells, normal heterodimeric TCRs or synthetic chimeric Ag receptors (CARs). TCRs recognize peptide-HLA complexes whereas CARs typically use an Ab-derived single-chain fragments variable that recognizes cancer-associated cell-surface Ags. Although both receptors mediate diverse effector functions, a quantitative comparison of the sensitivity and signaling capacity of TCRs and CARs has been limited due to their differences in affinities and ligands. In this study we describe their direct comparison by using TCRs that could be formatted either as conventional αβ heterodimers, or as single-chain fragments variabl

SUBMITTER: Harris DT 

PROVIDER: S-EPMC5780198 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature