Human NK Cells Downregulate Zap70 and Syk in Response to Prolonged Activation or DNA Damage.

ABSTRACT: The extent of NK cell activity during the innate immune response affects downstream immune functions and, ultimately, the outcome of infectious or malignant disease. However, the mechanisms that terminate human NK cell responses have yet to be defined. When activation receptors expressed on NK cell surfaces bind to ligands on diseased cells, they initiate a signal that is propagated by a number of intracellular kinases, including Zap70 and Syk, eventually leading to NK cell activation. We assayed Zap70 and Syk content in NK cells from healthy human donors and identified a subset of NK cells with unusually low levels of these two kinases. We found that this Zap70^lowSyk^low subset consisted of NK cells expressing a range of surface markers, including CD56^hi an

SUBMITTER: Pugh JL 

PROVIDER: S-EPMC5780205 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature