Antiviral CD8 T cells induce Zika-virus-associated paralysis in mice.

ABSTRACT: Zika virus (ZIKV) is an emerging, mosquito-borne RNA virus. The rapid spread of ZIKV within the Americas has unveiled microcephaly ¹ and Guillain-Barré syndrome^2,3 as ZIKV-associated neurological complications. Recent reports have also indicated other neurological manifestations to be associated with ZIKV, including myelitis ⁴ , meningoencephalitis ⁵ and fatal encephalitis ⁶ . Here, we investigate the neuropathogenesis of ZIKV infection in type I interferon receptor IFNAR knockout (Ifnar1 ^-/- ) mice, an infection model that exhibits high viral burden within the central nervous system. We show that systemic spread of ZIKV from the site of infection to the brain requires Ifnar1 deficiency in the haematopoietic compartment. How

SUBMITTER: Jurado KA 

PROVIDER: S-EPMC5780207 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature