Long-term sequelae in survivors of childhood leukemia with Down syndrome: A childhood cancer survivor study report.

ABSTRACT:

Background

Children with Down syndrome (DS) are at increased risk of developing acute leukemia and are more prone to acute toxicities. We studied the incidence and severity of chronic health conditions among survivors of childhood leukemia with DS compared with those without DS.

Methods

Chronic health conditions reported by questionnaire were compared between 154 pediatric leukemia survivors with DS and 581 without DS, matched by leukemia, age at diagnosis, race/ethnicity, sex, radiation location and chemotherapy exposure using Cox models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Subjects were selected from 7139 5-year survivors of leukemia in the Childhood Cancer Survivor Study.

Results

Risk of at least 1 late onset chronic health condition

SUBMITTER: Goldsby RE 

PROVIDER: S-EPMC5780223 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature