The Chemokine Receptor CXCR3 Promotes CD8⁺ T Cell Accumulation in Uninfected Salivary Glands but Is Not Necessary after Murine Cytomegalovirus Infection.

ABSTRACT: Recent work indicates that salivary glands are able to constitutively recruit CD8⁺ T cells and retain them as tissue-resident memory T cells, independently of local infection, inflammation, or Ag. To understand the mechanisms supporting T cell recruitment to the salivary gland, we compared T cell migration to the salivary gland in mice that were infected or not with murine CMV (MCMV), a herpesvirus that infects the salivary gland and promotes the accumulation of salivary gland tissue-resident memory T cells. We found that acute MCMV infection increased rapid T cell recruitment to the salivary gland but that equal numbers of activated CD8⁺ T cells eventually accumulated in infected and uninfected glands. T cell recruitment to uninfected salivary glands depended on chem

SUBMITTER: Caldeira-Dantas S 

PROVIDER: S-EPMC5780235 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature