Carotid Intima-Media Thickness Is Associated With White Matter Hyperintensities: The Northern Manhattan Study.

ABSTRACT:

Background and purpose

Brain white matter hyperintensities (WMH) have been associated with increased risk of stroke, cognitive decline, and dementia. WMH can be a manifestation of small vessel disease, although the total microvascular contribution to multifactorial WMH pathophysiology remains unknown. We hypothesized a possible relationship between carotid intima-media thickness (cIMT), an ultrasound imaging marker of subclinical vascular disease, and brain WMH in a multiethnic, elderly stroke-free community-based cohort.

Methods

We evaluated the relationship between cIMT and WMH in the population-based Northern Manhattan Study, among individuals free of stroke. We used linear regression to examine the association of continuous measures of cIMT with quantitatively derived WM

SUBMITTER: Della-Morte D 

PROVIDER: S-EPMC5780238 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature