A tethering directing group strategy for ruthenium-catalyzed intramolecular alkene hydroarylation.

ABSTRACT: We report a new catalyst design for N-heterocycle synthesis that utilizes an alkene-tethered amide moiety as a directing group for aromatic C-H activation. This tethering directing group strategy is demonstrated in a ruthenium-catalyzed intramolecular alkene hydroarylation with N-aryl acrylamides to form oxindole products.

SUBMITTER: Kilaru P 

PROVIDER: S-EPMC5780245 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature