Intergenerational transfer of antibiotic-perturbed microbiota enhances colitis in susceptible mice.

ABSTRACT: Antibiotic exposure in children has been associated with the risk of inflammatory bowel disease (IBD). Antibiotic use in children or in their pregnant mother can affect how the intestinal microbiome develops, so we asked whether the transfer of an antibiotic-perturbed microbiota from mothers to their children could affect their risk of developing IBD. Here we demonstrate that germ-free adult pregnant mice inoculated with a gut microbial community shaped by antibiotic exposure transmitted their perturbed microbiota to their offspring with high fidelity. Without any direct or continued exposure to antibiotics, this dysbiotic microbiota in the offspring remained distinct from controls for at least 21 weeks. By using both IL-10-deficient and wild-type mothers, we showed that both inoculum and

SUBMITTER: Schulfer AF 

PROVIDER: S-EPMC5780248 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature