Effects of processing on structural, mechanical and biological properties of collagen-based substrates for regenerative medicine.

ABSTRACT: The aim of this work was to investigate the structural features of type I collagen isoforms and collagen-based films at atomic and molecular scales, in order to evaluate whether and to what extent different protocols of slurry synthesis may change the protein structure and the final properties of the developed scaffolds. Wide Angle X-ray Scattering data on raw materials demonstrated the preferential orientation of collagen molecules in equine tendon-derived collagens, while randomly oriented molecules were found in bovine skin collagens, together with a lower crystalline degree, analyzed by the assessment of FWHM (Full Width at Half Maximum), and a certain degree of salt contamination. WAXS and FT-IR (Fourier Transform Infrared) analyses on bovine collagen-based films, showed that mechanic

SUBMITTER: Terzi A 

PROVIDER: S-EPMC5780384 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature