Thrombosis and Vascular Inflammation in Diabetes: Mechanisms and Potential Therapeutic Targets.

ABSTRACT: Cardiovascular disease remains the main cause of morbidity and mortality in patients with diabetes. The risk of vascular ischemia is increased in this population and outcome following an event is inferior compared to individuals with normal glucose metabolism. The reasons for the adverse vascular profile in diabetes are related to a combination of more extensive atherosclerotic disease coupled with an enhanced thrombotic environment. Long-term measures to halt the accelerated atherosclerotic process in diabetes have only partially addressed vascular pathology, while long-term antithrombotic management remains largely similar to individuals without diabetes. We address in this review the pathophysiological mechanisms responsible for atherosclerosis with special emphasis on diabetes-related

SUBMITTER: Pechlivani N 

PROVIDER: S-EPMC5780411 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature