Magneto-active substrates for local mechanical stimulation of living cells.

ABSTRACT: Cells are able to sense and react to their physical environment by translating a mechanical cue into an intracellular biochemical signal that triggers biological and mechanical responses. This process, called mechanotransduction, controls essential cellular functions such as proliferation and migration. The cellular response to an external mechanical stimulation has been investigated with various static and dynamic systems, so far limited to global deformations or to local stimulation through discrete substrates. To apply local and dynamic mechanical constraints at the single cell scale through a continuous surface, we have developed and modelled magneto-active substrates made of magnetic micro-pillars embedded in an elastomer. Constrained and unconstrained substrates are analysed to map s

SUBMITTER: Bidan CM 

PROVIDER: S-EPMC5780514 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature