Immune Tolerance to Apoptotic Self Is Mediated Primarily by Regulatory B1a Cells.

ABSTRACT: The chronic autoimmune inflammatory diseases, systemic lupus erythematosus and Sjogren's syndrome, develop when tolerance to apoptotic cells (ACs) is lost. We have previously reported that this tolerance is maintained by innate-like, IL-10 secreting regulatory B cells. Two questions remained. First, do these regulatory B cells belong predominantly to a single subset of steady-state B cells and second, what is their specificity? We report here that innate-like B cells with markers characteristic for B1a cells (CD43^+veCD19^hiCD5^+veIgM^hiIgD^lo) constitute 80% of splenic and 96% of peritoneal B cells that respond to ACs by secreting IL-10. AC responsive B1a cells secrete self-reactive natural antibodies (NAbs) and IL-10, which is augmented b

SUBMITTER: Miles K 

PROVIDER: S-EPMC5780629 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature