Kinetics of organ response and survival following normalization of the serum free light chain ratio in AL amyloidosis.

ABSTRACT: Despite successful treatment of the clonal plasma cell implicated in its pathogenesis, patients with AL amyloidosis (AL) experience significant morbidity related to underlying amyloid mediated organ dysfunction. While normalization of the serum free light chain measurements [normal ratio of involved and uninvolved free light chains (nFLCr)] is the goal of therapy and centerpiece of hematologic response criteria, achieving (or not achieving) meaningful organ response (OR) is clinically significant for its implications on long-term symptomatology as well as overall survival (OS), and remains the ultimate goal of treatment. Expectations for organ recovery following successful therapy leading to nFLCr in AL remain poorly described. We evaluated the timeframe and predictive factors for OR, and

SUBMITTER: Kaufman GP 

PROVIDER: S-EPMC5780648 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature