Comparative efficacy and acceptability of antiepileptic drugs for classical trigeminal neuralgia: a Bayesian network meta-analysis protocol.

ABSTRACT:

Introduction

Trigeminal neuralgia (TN) affects 4 to 28.9/100 000 people worldwide, and antiepileptic drugs such as carbamazepine and oxcarbazepine are the firstline treatment options. However, the efficacy and safety of other antiepileptic drugs remain unclear due to insufficient direct comparisons.

Objective

To compare the efficacy and acceptability of all currently available antiepileptic agents for the treatment of patients with classical TN.

Methods

We will search the PubMed, EMBASE, Cochrane Library and Web of Science databases for unpublished or undergoing research listed in registry platforms. We will include all randomised controlled trials comparing two different antiepileptic drugs or one antiepileptic drug with placebo in patients with classical TN. The pri

SUBMITTER: Qin Z 

PROVIDER: S-EPMC5780694 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature