Observational study of the differential impact of time-varying depressive symptoms on all-cause and cause-specific mortality by health status in community-dwelling adults: the REGARDS study.

ABSTRACT:

Objective

To assess the association between time-varying depressive symptoms with all-cause and cause-specific mortality.

Design

The REGARDS (Reasons for Geographic and Racial Differences in Stroke) is a national, population-based longitudinal study conducted from 2003 to 2007.

Setting

General continental US communities.

Participants

29 491 black and white US adults ≥45 years randomly sampled within race-sex-geographical strata.

Exposure

Elevated depressive symptoms (Centre for Epidemiologic Studies Depression (CES-D) 4≥4) measured at baseline and on average 5 and 7 years later.

Main outcome measures

Cox proportional hazard regression models assessed cancer, non-cardiovascular (cardiovascular disease (CVD)), CVD and all-cause mortality.

Results

SUBMITTER: Moise N 

PROVIDER: S-EPMC5780736 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature