Characteristics of functional enrichment and gene expression level of human putative transcriptional target genes.

ABSTRACT:

Background

Transcriptional target genes show functional enrichment of genes. However, how many and how significantly transcriptional target genes include functional enrichments are still unclear. To address these issues, I predicted human transcriptional target genes using open chromatin regions, ChIP-seq data and DNA binding sequences of transcription factors in databases, and examined functional enrichment and gene expression level of putative transcriptional target genes.

Results

Gene Ontology annotations showed four times larger numbers of functional enrichments in putative transcriptional target genes than gene expression information alone, independent of transcriptional target genes. To compare the number of functional enrichments of putative transcriptional target gen

SUBMITTER: Osato N 

PROVIDER: S-EPMC5780744 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature