Examining patterns of multimorbidity, polypharmacy and risk of adverse drug reactions in chronic obstructive pulmonary disease: a cross-sectional UK Biobank study.

ABSTRACT:

Objective

This study aims: (1) to describe the pattern and extent of multimorbidity and polypharmacy in UK Biobank participants with chronic obstructive pulmonary disease (COPD) and (2) to identify which comorbidities are associated with increased risk of adverse drug reactions (ADRs) resulting from polypharmacy.

Design

Cross-sectional.

Setting

Community cohort.

Participants

UK Biobank participants comparing self-reported COPD (n=8317) with no COPD (n=494 323).

Outcomes

Multimorbidity (≥4 conditions) and polypharmacy (≥5 medications) in participants with COPD versus those without. Risk of ADRs (taking ≥3 medications associated with falls, constipation, urinary retention, central nervous system (CNS) depression, bleeding or renal injury) in relation to th

SUBMITTER: Hanlon P 

PROVIDER: S-EPMC5781016 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature