Estimating age-specific cumulative incidence for the 2009 influenza pandemic: a meta-analysis of A(H1N1)pdm09 serological studies from 19 countries.

ABSTRACT:

Background

The global impact of the 2009 influenza A(H1N1) pandemic (H1N1pdm) is not well understood.

Objectives

We estimate overall and age-specific prevalence of cross-reactive antibodies to H1N1pdm virus and rates of H1N1pdm infection during the first year of the pandemic using data from published and unpublished H1N1pdm seroepidemiological studies.

Methods

Primary aggregate H1N1pdm serologic data from each study were stratified in standardized age groups and evaluated based on when sera were collected in relation to national or subnational peak H1N1pdm activity. Seropositivity was assessed using well-described and standardized hemagglutination inhibition (HI titers ≥ 32 or ≥ 40) and microneutralization (MN ≥ 40) laboratory assays. The prevalence of cross-reactive

SUBMITTER: Van Kerkhove MD 

PROVIDER: S-EPMC5781221 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature