Comparative efficacy and tolerability of new-generation antidepressants for major depressive disorder in children and adolescents: protocol of an individual patient data meta-analysis.

ABSTRACT:

Introduction

Although previous conventional meta-analyses and network meta-analyses have provided some important findings about pharmacological treatments for children and adolescents with depressive disorders in the past decades, several questions still remain unsolved by the aggregate data from those meta-analyses. Individual participant data meta-analysis (IPD-MA) enables exploration of the impacts of individual characteristics on treatment effects, allowing matching of treatments to specific subgroups of patients. We will perform an IPD-MA to assess the efficacy and tolerability of new-generation antidepressants for major depressive disorder in children and adolescents.

Methods and analysis

We will systematically search for all double-blind randomised controlled trials (

SUBMITTER: Zhou X 

PROVIDER: S-EPMC5781225 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature