Residential proximity to abandoned uranium mines and serum inflammatory potential in chronically exposed Navajo communities.

ABSTRACT: Members of the Navajo Nation, who possess a high prevalence of cardiometabolic disease, reside near hundreds of local abandoned uranium mines (AUM), which contribute uranium, arsenic and other metals to the soil, water and air. We recently reported that hypertension is associated with mine waste exposures in this population. Inflammation is a major player in the development of numerous vascular ailments. Our previous work establishing that specific transcriptional responses of cultured endothelial cells treated with human serum can reveal relative circulating inflammatory potential in a manner responsive to pollutant exposures, providing a model to assess responses associated with exposure to these waste materials in this population. To investigate a potential link between exposures to AUM

SUBMITTER: Harmon ME 

PROVIDER: S-EPMC5781233 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature