Adjunctive therapy for severe malaria: a review and critical appraisal.

ABSTRACT: BACKGROUND:Despite recent efforts and successes in reducing the malaria burden globally, this infection still accounts for an estimated 212 million clinical cases, 2 million severe malaria cases, and approximately 429,000 deaths annually. Even with the routine use of effective anti-malarial drugs, the case fatality rate for severe malaria remains unacceptably high, with cerebral malaria being one of the most life-threatening complications. Up to one-third of cerebral malaria survivors are left with long-term cognitive and neurological deficits. From a population point of view, the decrease of malaria transmission may jeopardize the development of naturally acquired immunity against the infection, leading to fewer total cases, but potentially an increase in severe cases. The pathophysiology

SUBMITTER: Varo R 

PROVIDER: S-EPMC5781278 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature