Association Between Radiation Therapy, Surgery, or Observation for Localized Prostate Cancer and Patient-Reported Outcomes After 3 Years.

ABSTRACT:

Importance

Understanding the adverse effects of contemporary approaches to localized prostate cancer treatment could inform shared decision making.

Objective

To compare functional outcomes and adverse effects associated with radical prostatectomy, external beam radiation therapy (EBRT), and active surveillance.

Design, setting, and participants

Prospective, population-based, cohort study involving 2550 men (≤80 years) diagnosed in 2011-2012 with clinical stage cT1-2, localized prostate cancer, with prostate-specific antigen levels less than 50 ng/mL, and enrolled within 6 months of diagnosis.

Exposures

Treatment with radical prostatectomy, EBRT, or active surveillance was ascertained within 1 year of diagnosis.

Main outcomes and measures

Patient-reported

SUBMITTER: Barocas DA 

PROVIDER: S-EPMC5782813 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature