Single-Cell RNA-Seq Reveals Hypothalamic Cell Diversity.

ABSTRACT: The hypothalamus is one of the most complex brain structures involved in homeostatic regulation. Defining cell composition and identifying cell-type-specific transcriptional features of the hypothalamus is essential for understanding its functions and related disorders. Here, we report single-cell RNA sequencing results of adult mouse hypothalamus, which defines 11 non-neuronal and 34 neuronal cell clusters with distinct transcriptional signatures. Analyses of cell-type-specific transcriptomes reveal gene expression dynamics underlying oligodendrocyte differentiation and tanycyte subtypes. Additionally, data analysis provides a comprehensive view of neuropeptide expression across hypothalamic neuronal subtypes and uncover Crabp1⁺ and Pax6⁺ neuronal populations in spec

SUBMITTER: Chen R 

PROVIDER: S-EPMC5782816 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature