Strongly enhanced colorectal cancer risk stratification by combining family history and genetic risk score.

ABSTRACT:

Background and aim

Family history (FH) and genetic risk scores (GRSs) are increasingly used for risk stratification for colorectal cancer (CRC) screening. However, they were mostly considered alternatively rather than jointly. The aim of this study was to assess the potential of individual and joint risk stratification for CRC by FH and GRS.

Patients and methods

A GRS was built based on the number of risk alleles in 53 previously identified single-nucleotide polymorphisms among 2,363 patients with a first diagnosis of CRC and 2,198 controls in DACHS [colorectal cancer: chances for prevention through screening], a population-based case-control study in Germany. Associations between GRS and FH with CRC risk were quantified by multiple logistic regression.

Results

A tota

SUBMITTER: Weigl K 

PROVIDER: S-EPMC5783152 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature