Nestin expression is dynamically regulated in cardiomyocytes during embryogenesis.

ABSTRACT: The transcriptional factors implicated in the expression of the intermediate filament protein nestin in cardiomyocytes during embryogenesis remain undefined. In the heart of 9,5-10,5 day embryonic mice, nestin staining was detected in atrial and ventricular cardiomyocytes and a subpopulation co-expressed Tbx5. At later stages of development, nestin immunoreactivity in cardiomyocytes gradually diminished and was absent in the heart of 17,5 day embryonic mice. In the heart of wild type 11,5 day embryonic mice, 54 ± 7% of the trabeculae expressed nestin and the percentage was significantly increased in the hearts of Tbx5^+/- and Gata4^+/- embryos. The cell cycle protein Ki67 and transcriptional coactivator Yap-1 were still prevalent in the nucleus of nestin⁽⁺⁾ -

SUBMITTER: Hertig V 

PROVIDER: S-EPMC5783184 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature