The Aging Astrocyte Transcriptome from Multiple Regions of the Mouse Brain.

ABSTRACT: Aging brains undergo cognitive decline, associated with decreased neuronal synapse number and function and altered metabolism. Astrocytes regulate neuronal synapse formation and function in development and adulthood, but whether these properties change during aging, contributing to neuronal dysfunction, is unknown. We addressed this by generating aged and adult astrocyte transcriptomes from multiple mouse brain regions. These data provide a comprehensive RNA-seq database of adult and aged astrocyte gene expression, available online as a resource. We identify astrocyte genes altered by aging across brain regions and regionally unique aging changes. Aging astrocytes show minimal alteration of homeostatic and neurotransmission-regulating genes. However, aging astrocytes upregulate genes that

SUBMITTER: Boisvert MM 

PROVIDER: S-EPMC5783200 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature