Intrinsic functional connectivity variance and state-specific under-connectivity in autism.

ABSTRACT: Autism spectrum disorder (ASD) is a neurodevelopmental condition associated with altered brain connectivity. Previous neuroimaging research demonstrates inconsistent results, particularly in studies of functional connectivity in ASD. Typically, these inconsistent findings are results of studies using static measures of resting-state functional connectivity. Recent work has demonstrated that functional brain connections are dynamic, suggesting that static connectivity metrics fail to capture nuanced time-varying properties of functional connections in the brain. Here we used a dynamic functional connectivity approach to examine the differences in the strength and variance of dynamic functional connections between individuals with ASD and healthy controls (HCs). The variance of dynamic funct

SUBMITTER: Chen H 

PROVIDER: S-EPMC5783325 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature