Relation of body mass index to risk of developing inflammatory bowel disease amongst women in the Danish National Birth Cohort.

ABSTRACT:

Background

Crohn's disease (CD) has traditionally been associated with weight loss and low BMI, yet paradoxically obesity has recently been suggested as a risk factor for CD, but not for ulcerative colitis (UC). We therefore hypothesized that the relation between BMI and CD is U shaped.

Aim

To conduct a large population-based prospective cohort study of BMI and later risk of IBD, taking age at IBD diagnosis into account.

Methods

A cohort of 74,512 women from the Danish National Birth Cohort, with BMI measured pre-pregnancy and 18 months after delivery, was followed for 1,022,250 person-years for development of IBD, according to the Danish National Patient Register. Associations were tested by Cox regression.

Results

Overweight subjects (25≤BMI<30 kg/m2) had the

SUBMITTER: Mendall M 

PROVIDER: S-EPMC5783332 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature