Serum calcification propensity is independently associated with disease activity in systemic lupus erythematosus.

ABSTRACT:

Background

Systemic lupus erythematosus (SLE) is associated with severe cardiovascular complications. The T50 score is a novel functional blood test quantifying calcification propensity in serum. High calcification propensity (or low T50) is a strong and independent determinant of all-cause mortality in various patient populations.

Methods

A total of 168 patients with ≥ 4 American College of Rheumatology (ACR) diagnostic criteria from the Swiss Systemic lupus erythematosus Cohort Study (SSCS) were included in this analysis. Serum calcification propensity was assessed using time-resolved nephelometry.

Results

The cohort mainly consisted of female (85%), middle-aged (43±14 years) Caucasians (77%). The major determinants of T50 levels included hemoglobin, serum creatinin

SUBMITTER: Dahdal S 

PROVIDER: S-EPMC5783342 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature