Prognostic value of presepsin in adult patients with sepsis: Systematic review and meta-analysis.

ABSTRACT:

Objective

Presepsin is a novel biomarker to diagnose sepsis but its prognostic value has not been comprehensively reviewed. We conducted this meta-analysis to evaluate the mortality prediction value of presepsin in sepsis.

Methods

We searched comprehensive electronic databases from PubMed, EMBASE, and Cochrane Library through September 2017 using the key words of ('presepsin' or 'sCD14-ST' or 'soluble CD14 subtype') and ('sepsis' or 'septic shock') and ('prognosis' or 'prognostic value' or 'prognostic biomarker' or 'mortality'). We extracted the presepsin levels in survivors and non-survivors from each individual study and evaluated the standardized mean difference (SMD) using a web-based meta-analysis with the R statistical analysis program.

Results

A total of 10 stu

SUBMITTER: Yang HS 

PROVIDER: S-EPMC5783380 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature