Removal of stabilizers from human serum albumin by adsorbents and dialysis used in blood purification.

ABSTRACT:

Introduction

Human serum albumin (HSA) is a monomeric multi-domain protein that possesses an extraordinary binding capacity. It plays an important role in storing and transporting endogenous substances, metabolites, and drugs throughout the human circulatory system. Clinically, HSA is used to treat a variety of diseases such as hypovolemia, shock, burns, hemorrhage, and trauma in critically ill patients. Pharmaceutical-grade HSA contains the stabilizers sodium caprylate and N-acetyltryptophanate to protect the protein from oxidative stress and to stabilize it for heat treatment which is applied for virus inactivation.

Material and methods

The aim of this study was to determine if the two stabilizers can be depleted by adsorbent techniques. Several, adsorbents, some of them a

SUBMITTER: Harm S 

PROVIDER: S-EPMC5783404 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature