Glass promotes the differentiation of neuronal and non-neuronal cell types in the Drosophila eye.

ABSTRACT: Transcriptional regulators can specify different cell types from a pool of equivalent progenitors by activating distinct developmental programs. The Glass transcription factor is expressed in all progenitors in the developing Drosophila eye, and is maintained in both neuronal and non-neuronal cell types. Glass is required for neuronal progenitors to differentiate as photoreceptors, but its role in non-neuronal cone and pigment cells is unknown. To determine whether Glass activity is limited to neuronal lineages, we compared the effects of misexpressing it in neuroblasts of the larval brain and in epithelial cells of the wing disc. Glass activated overlapping but distinct sets of genes in these neuronal and non-neuronal contexts, including markers of photoreceptors, cone cells and pigment c

SUBMITTER: Morrison CA 

PROVIDER: S-EPMC5783423 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature