DNER modulates the length, polarity and synaptogenesis of spiral ganglion neurons via the Notch signaling pathway.

ABSTRACT: The Delta/Notch‑like epidermal growth factor‑related receptor (DNER) serves an important role in the developing central nervous system. However, the actions of DNER in the development of the spiral ganglion in the inner ear have yet to be elucidated. Wild‑type C57BL/6 mice were housed and time‑mated for use in the present study. Primary neuronal cultures were prepared using spiral ganglion progenitors isolated from the modiolus of postnatal day 1 (P1) mice. DNER recombinant lentiviral vectors were constructed and transfected into the cultured primary neurons. The relative proportion of differentiated neurons and the length of their neurites were evaluated using microscopy. The results of the present study demonstrated that DNER was expressed in spiral ganglion neurons (SGNs) that exhibited

SUBMITTER: Du J 

PROVIDER: S-EPMC5783477 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature