Diagnostic significance and potential function of miR-338-5p in hepatocellular carcinoma: A bioinformatics study with microarray and RNA sequencing data.

ABSTRACT: MicroRNA (miR)-338-5p has been studied in hepatocellular carcinoma (HCC); however, the diagnostic value and molecular mechanism underlying its actions remains to be elucidated. The present study aimed to validate the diagnostic ability of miR‑338‑5p and further explore the underlying molecular mechanism. Data from eligible studies, Gene Expression Omnibus (GEO) chips and The Cancer Genome Atlas (TCGA) datasets were gathered in the data mining and the integrated meta‑analysis, to evaluate the significance of miR‑338‑5p in diagnosing HCC comprehensively. The potential target genes of miR‑338‑5p were achieved from the intersection of the deregulated targets of miR‑338‑5p from GEO and TCGA in addition to the predicted target genes from 12 online software. A protein‑protein‑interaction (PPI) ne

SUBMITTER: Liang L 

PROVIDER: S-EPMC5783480 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature