Molecular basis of coronary artery dilation and aneurysms in patients with Kawasaki disease based on differential protein expression.

ABSTRACT: Kawasaki disease (KD) is an acquired cardiac disease with a high incidence that affects children. KD has various complications, including coronary artery dilation (CAD) and coronary artery aneurysms (CAA). The identification of differentially expressed proteins and the underlying mechanisms may be the key to understanding differences between these KD complications. In the present study, isobaric tags for relative and absolute quantitation were used to identify variations in serum proteins between KD patients with CAD and CAA. In total, 87 (37 upregulated and 50 downregulated) and 65 (33 upregulated and 32 downregulated) significantly differentially‑expressed proteins were identified in comparisons between control samples (healthy individuals) and those obtained from patients with KD and wi

SUBMITTER: Liu W 

PROVIDER: S-EPMC5783486 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature