Endocrine Disruption in Human Fetal Testis Explants by Individual and Combined Exposures to Selected Pharmaceuticals, Pesticides, and Environmental Pollutants.

ABSTRACT:

Background

Numerous chemicals are capable of disrupting androgen production, but the possibility that they might act together to produce effects greater than those of the most effective component in the mixture has not been studied directly in human tissues. Suppression of androgen synthesis in fetal life has been associated with testis maldescent, malformations of the genitalia at birth, and poor semen quality later in life.

Objectives

Our aim was to investigate whether chemicals can act together to disrupt androgen production in human fetal testis explants and to evaluate the importance of mixture effects when characterizing the hazard of individual chemicals.

Methods

We used an organotypic culture system of human fetal testes explants called FEtal Gonad Assay (FEGA

SUBMITTER: Gaudriault P 

PROVIDER: S-EPMC5783658 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature