Image-based computational assessment of vascular wall mechanics and hemodynamics in pulmonary arterial hypertension patients.

ABSTRACT: Pulmonary arterial hypertension (PAH) is a disease characterized by an elevated pulmonary arterial (PA) pressure. While several computational hemodynamic models of the pulmonary vasculature have been developed to understand PAH, they are lacking in some aspects, such as the vessel wall deformation and its lack of calibration against measurements in humans. Here, we describe a computational modeling framework that addresses these limitations. Specifically, computational models describing the coupling of hemodynamics and vessel wall mechanics in the pulmonary vasculature of a PAH patient and a normal subject were developed. Model parameters, consisting of linearized stiffness E of the large vessels and Windkessel parameters for each outflow branch, were calibrated against in vivo measurement

SUBMITTER: Zambrano BA 

PROVIDER: S-EPMC5783768 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature