Conjugated Linoleic Acid Modulates Clinical Responses to Oral Nitrite and Nitrate.

ABSTRACT: Dietary NO₃^- (nitrate) and NO₂^- (nitrite) support ˙NO (nitric oxide) generation and downstream vascular signaling responses. These nitrogen oxides also generate secondary nitrosating and nitrating species that react with low molecular weight thiols, heme centers, proteins, and unsaturated fatty acids. To explore the kinetics of NO₃^-and NO₂^-metabolism and the impact of dietary lipid on nitrogen oxide metabolism and cardiovascular responses, the stable isotopes Na¹⁵NO₃ and Na¹⁵NO₂ were orally administered in the presence or absence of conjugated linoleic acid (cLA). The reduction of ¹⁵NO₂^- to ¹⁵NO was indicated by elec

SUBMITTER: Hughan KS 

PROVIDER: S-EPMC5783786 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature