Racemization at the Asp 58 residue in αA-crystallin from the lens of high myopic cataract patients.

ABSTRACT: Post-translational modifications in lens proteins are key causal factors in cataract. As the most abundant post-translational modification in the lens, racemization may be closely related to the pathogenesis of cataract. Racemization of αA-crystallin, a crucial structural and heat shock protein in the human lens, could significantly influence its structure and function. In previous studies, elevated racemization from l-Asp 58 to d-isoAsp58 in αA-crystallin has been found in age-related cataract (ARC) lenses compared to normal aged human lenses. However, the role of racemization in high myopic cataract (HMC), which is characterized by an early onset of nuclear cataract, remains unknown. In the current study, apparently different from ARC, significantly increased racemization from l-Asp 58 t

SUBMITTER: Zhu XJ 

PROVIDER: S-EPMC5783843 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature