TIPE1 suppresses invasion and migration through down-regulating Wnt/β-catenin pathway in gastric cancer.

ABSTRACT: Epithelial-mesenchymal transition (EMT) plays an important role in the invasiveness and metastasis of gastric cancer. Therefore, identifying key molecules involved in EMT will provide new therapeutic strategy for treating patients with gastric cancer. TIPE1 is a newly identified member of the TIPE (TNFAIP8) family, and its contributions to progression and metastasis have not been evaluated. In this study, we found that the levels of TIPE1 were significantly reduced and inversely correlated with differentiation status and distant metastasis in primary gastric cancer tissues. We further observed overexpression of TIPE1 in aggressive gastric cancer cell lines decreased their metastatic properties both in vitro and in vivo as demonstrated by markedly inhibiting EMT and metastasis of gastric ca

SUBMITTER: Liu W 

PROVIDER: S-EPMC5783849 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature