Ontology highlight
ABSTRACT:
SUBMITTER: Raposo B
PROVIDER: S-EPMC5783942 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Raposo Bruno B Merky Patrick P Lundqvist Christina C Yamada Hisakata H Urbonaviciute Vilma V Niaudet Colin C Viljanen Johan J Kihlberg Jan J Kyewski Bruno B Ekwall Olov O Holmdahl Rikard R Bäcklund Johan J
Nature communications 20180124 1
Establishing effective central tolerance requires the promiscuous expression of tissue-restricted antigens by medullary thymic epithelial cells. However, whether central tolerance also extends to post-translationally modified proteins is not clear. Here we show a mouse model of autoimmunity in which disease development is dependent on post-translational modification (PTM) of the tissue-restricted self-antigen collagen type II. T cells specific for the non-modified antigen undergo efficient centr ...[more]