Cilostazol-Loaded Poly(ε-Caprolactone) Electrospun Drug Delivery System for Cardiovascular Applications.

ABSTRACT:

Purpose

The study discusses the value of electrospun cilostazol-loaded (CIL) polymer structures for potential vascular implant applications.

Methods

Biodegradable polycaprolactone (PCL) fibers were produced by electrospinning on a rotating drum collector. Three different concentrations of CIL: 6.25%, 12.50% and 18.75% based on the amount of polymer, were incorporated into the fibers. The fibers were characterized by their size, shape and orientation. Materials characterization was carried out by Fourier Transformed Infrared spectroscopy (FTIR), Raman spectroscopy, differential scanning calorimetry (DSC) and X-ray diffraction (XRD). In vitro drug release study was conducted using flow-through cell apparatus (USP 4).

Results

Three-dimensional structures characterized by

SUBMITTER: Rychter M 

PROVIDER: S-EPMC5784006 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature