Mechanosensitive ion channel Piezo1 is expressed in antral G cells of murine stomach.

ABSTRACT: G cells in the antrum region of the murine stomach produce gastrin, the central hormone for controlling gastric activities. Secretion of gastrin is induced mainly by protein breakdown products but also by distensions of the stomach wall. Although G cells respond to protein fragments via distinct chemosensory receptor types, the mechanism underlying G cell activation upon distention is entirely ambiguous. Mechanosensitive ion channels are considered as potential candidates for such a task. Therefore, we explore the possibility of whether Piezo1, a polymodal sensor for diverse mechanical forces, is expressed in antral G cells. The experimental analyses revealed that the vast majority of G cells indeed expressed Piezo1. Within flask-like G cells at the base of the antral invaginations, the Pi

SUBMITTER: Lang K 

PROVIDER: S-EPMC5784007 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature