Genome-wide association study of paclitaxel and carboplatin disposition in women with epithelial ovarian cancer.

ABSTRACT: Identifying single nucleotide polymorphisms (SNPs) that influence chemotherapy disposition may help to personalize cancer treatment and limit toxicity. Genome-wide approaches are unbiased, compared with candidate gene studies, but usually require large cohorts. As most chemotherapy is given cyclically multiple blood sampling is required to adequately define drug disposition, limiting patient recruitment. We found that carboplatin and paclitaxel disposition are stable phenotypes in ovarian cancer patients and tested a genome-wide association study (GWAS) design to identify SNPs associated with chemotherapy disposition. We found highly significant SNPs in ABCC2, a known carboplatin transporter, associated with carboplatin clearance (asymptotic P = 5.2 × 10⁶, empirical P = 1.4 × 10

SUBMITTER: Gao B 

PROVIDER: S-EPMC5784122 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature