Mitochondrial fission is associated with UCP1 activity in human brite/beige adipocytes.

ABSTRACT:

Objective

Thermogenic adipocytes (i.e. brown or brite/beige adipocytes) are able to burn large amounts of lipids and carbohydrates as a result of highly active mitochondria and enhanced uncoupled respiration, due to UCP1 activity. Although mitochondria are the key organelles for this thermogenic function, limited human data are available.

Methods/results

We characterized changes in the mitochondrial function of human brite adipocytes, using hMADS cells as a model of white- to brite-adipocyte conversion. We found that profound molecular modifications were associated with morphological changes in mitochondria. The fission process was partly driven by the DRP1 protein, which also promoted mitochondrial uncoupling.

Conclusion

Our data demonstrate that white-to-brite conve

SUBMITTER: Pisani DF 

PROVIDER: S-EPMC5784321 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature